Citation: HUANG Zi-Heng, ZOU Jian-Mei, LI Xiao-Qing, HE Qing, NIE Jin-Fang. Research Progress of Fluorescent Probe for G-quadruplex[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(8): 1258-1269. doi: 10.19756/j.issn.0253-3820.201797 shu

Research Progress of Fluorescent Probe for G-quadruplex

College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China

Corresponding author: ZOU Jian-Mei, NIE Jin-Fang,
Received Date: 28 December 2020
Revised Date: 14 May 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.21765007), the Guangxi Key Research Project (No.GuikeAB17129003), and the Natural Science Foundation of Guangxi, China (No.2020GXNSFBA297114).

G-quadruplex is a kind of secondary structure of nucleic acids that is formed by the stacking of guanine-rich oligonucleotides. It has been reported that G-quadruplexes widely locate in the human genome (Telomere, gene promoter and so on) and play important roles in regulation of gene transcription and expression, stabilization of gene and synthesis of telomere. This indicates that the structure, quantity and distribution of G-quadruplex in organism are related to the occurrence and development of various diseases to some extent. Therefore, the real-time monitoring of G-quadruplex in organism has great significance for the diagnosis and treatment of diseases. Fluorescence spectrometry technique shows many advantages such as high sensitivity and convenience in practice, and has become one of the main tools for detection and identification of G-quadruplex. Herein, the recent development of G-quadruplex fluorescent probes (including porphyrins, thiazole orange, Thioflavin T, etc.) and the research progress of biosensors and fluorescence cell imaging based on the specific recognition reaction between G-quadruplex and probes are reviewed.
- G-quadruplex,
- Fluorescent probe,
- Biosensor,
- Fluorescence cell imaging,
- Review
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