Citation: HAN Ya-Jing, WANG Feng-Lin, JIANG Jian-Hui. Progress and Applications of Chemodynamic Therapy in Cancer Therapy[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1121-1132. doi: 10.19756/j.issn.0253-3820.201734 shu

Progress and Applications of Chemodynamic Therapy in Cancer Therapy

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Corresponding author: WANG Feng-Lin, JIANG Jian-Hui,
Received Date: 7 December 2020
Revised Date: 21 April 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21527810, 91753107, 21705041).

Chemodynamic therapy (CDT) is receiving increasing attention for tumor therapy. In the presence of catalysts, H₂O₂ can be converted into ·OH that possesses stronger oxidation and higher toxicity through the Fenton or Fenton-like reaction utilizing the unique feature of tumor microenvironments such as weak acidity and excessive H₂O₂. The generated ·OH can disrupt the ROS homeostasis in tumor cells and leads to severe oxidative stress, which can cause DNA necrosis, protein inactivation, lipid oxidation and finally induce cell apoptosis or necrosis. CDT is characterized by high specificity and independence and it is especially suitable for the treatment of tumors in deep tissues. However, the development of CDT is still in its infancy, and its therapeutic efficiency is still not satisfactory. To improve the efficacy of CDT, three different strategies have been introduced, i.e., changing tumor microenvironment, selecting appropriate catalyst and substrate, and combining with other treatment methods. In this paper, we summarize the recent development of CDT in tumor treatment and briefly point out its application prospects.
- Chemodynamic therapy,
- Fenton therapy,
- Tumor microenvironment,
- Cancer therapy,
- Review
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