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化学动力学治疗在癌症治疗中的应用研究进展

韩雅静 ,  汪凤林 ,  蒋健晖

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引用本文: 韩雅静, 汪凤林, 蒋健晖. 化学动力学治疗在癌症治疗中的应用研究进展[J]. 分析化学, 2021, 49(7): 1121-1132. doi: 10.19756/j.issn.0253-3820.201734 shu
Citation:  HAN Ya-Jing,  WANG Feng-Lin,  JIANG Jian-Hui. Progress and Applications of Chemodynamic Therapy in Cancer Therapy[J]. Chinese Journal of Analytical Chemistry, 2021, 49(7): 1121-1132. doi: 10.19756/j.issn.0253-3820.201734 shu

化学动力学治疗在癌症治疗中的应用研究进展

  • 湖南大学化学化工学院 化学生物传感与计量学国家重点实验室, 长沙 410082

    • 通讯作者: 汪凤林,E-mail:fengliw@hnu.edu.cn; 蒋健晖,E-mail:jianhuijiang@hnu.edu.cn
  • 基金项目:

    国家自然科学基金项目（Nos.21527810，91753107，21705041）资助。

摘要: 化学动力学治疗（Chemodynamic therapy，CDT）在肿瘤治疗领域受到越来越多的关注。CDT借助于肿瘤微环境弱酸、H2O2过量的特性，利用Fenton或类-Fenton反应将弱氧化性的H2O2催化转化成强氧化性的·OH，导致细胞内氧化水平升高、DNA坏死、蛋白失活、脂质氧化，最终诱导癌细胞凋亡。CDT具有特异性和独立性强、适用于组织深处肿瘤的治疗的特点，是近年癌症治疗的研究热点。然而，CDT的研究还处于初级阶段，为提高治疗效率，研究者主要提出了3种方式：改变肿瘤微环境、选择合适的催化剂和反应底物及与其它治疗方式联合。本文对近年基于上述3种方式提高CDT癌症治疗效率的研究进展进行了评述，并对其应用前景进行了展望。

English


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  • 收稿日期:  2020-12-07
  • 修回日期:  2021-04-21
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