Citation: ZHANG Zhao-Hui, ZHOU Na-Jiao, LIU Xing, CHEN Ying-Zhuang, GUO Bin, MA Ming, CHEN Bo. Advances in Detection Methods for Aristolochic Acids in Medicine, Environment and Food[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(11): 1792-1803. doi: 10.19756/j.issn.0253-3820.201455 shu

Advances in Detection Methods for Aristolochic Acids in Medicine, Environment and Food

ZHANG Zhao-Hui ^1,2 ,
ZHOU Na-Jiao ¹ ,
LIU Xing ¹ ,
CHEN Ying-Zhuang ¹ ,
GUO Bin ¹ ,
MA Ming ^1,, ,
CHEN Bo ^1,,

1.
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education of China) and Key Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University, Changsha 410081, China;
2.
Hunan Biological and Electromechanical Polytechnic, Changsha 410127, China

Corresponding author: MA Ming, CHEN Bo,
Received Date: 1 August 2020
Revised Date: 8 August 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21775041, 21775040).

Aristolochic acids (AAs) are a kind of nitrophenanthrene compound in Aristolochiaceae plants. AAs are classified as the Class I carcinogen by the International Agency for Research on Cancer because of their irreversible nephrotoxicity. The analysis of AAs is of great significance for exploring the pathogenic mechanism and preventing from AAs nephropathy (AAN), Balkan endemic nephropathy (BEN) and chronic kidney disease (CKD). The present article summarizes and compares the common methods for detection of AAs, specifically focusing on the applications and the latest advances of high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS). The existential problems, the challenges, and the further development of the detection of AAs are fully discussed.
- Aristolochic acids,
- Nephrotoxicity,
- High performance liquid chromatography,
- Liquid chromatography-mass spectrometry,
- Detection method,
- Review
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