Citation: ZHANG Jia-Jun, DENG Wei-Heng, OU Shuo-Jun, WANG Zhi-Yuan, CEN Jian-Bin, CHEN Min-Dan, WANG Si-Wei, ZENG Guang-Feng. High Performance Liquid Chromatography-Tandem Quadrupole-Time of Flight-Mass Spectrometry for Determination of Indaziflam and Four Metabolites in Cereals[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(8): 1366-1374. doi: 10.19756/j.issn.0253-3820.201403 shu

High Performance Liquid Chromatography-Tandem Quadrupole-Time of Flight-Mass Spectrometry for Determination of Indaziflam and Four Metabolites in Cereals

1.
Guangzhou Customs Technology Center, Guangzhou 510623, China;
2.
Guangzhou Inspection and Certification Group Co. Ltd., Guangzhou 511447, China;
3.
Guangdong Provincial Key Laboratory of High Technology for Plant Protection, Institute of Plant Protection, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Corresponding author: WANG Si-Wei, ZENG Guang-Feng,
Received Date: 11 July 2020
Revised Date: 30 May 2021

Fund Project: Supported by the Sub Project of National Agricultural Product Quality and Safety Risk Assessment Major Special Project-Pesticide Residue Risk Assessment in Tropical Fruits (No.GJFP202002) and the Foundation of the Dean of Guangdong Academy of Agricultural Sciences (No.201707).

A high performance liquid chromatography-tandem quadrupole-time of flight-mass spectrometry (HPLC-Q-TOF/MS) method for determination of residues of indaziflam and its four metabolites (1-fluoroethyl triazinediamine, indaziflam-carboxylic acid, triazine-indanone and indaziflam-olefin) in cereal samples was developed. The samples were extracted by acetonitrile, and the supernatant was collected for purification after salting-out and centrifugation. Under the optimized chromatographic and mass spectrometric conditions, the data were collected by electrospray ionization (ESI) sources in positive ion mode. The calibration curves of five compounds showed good linearity in concentration range of 2.0-200 μg/L (R²>0.9987). The average recoveries were 79.3%-108.0% at three spiked levels (10, 20 and 100 μg/kg), while the relative standard deviations (RSD) were 1.2%-6.0%. The limits of detection and limits of quantification ranged from 0.05 to 0.60 μg/kg and 0.15 to 2.00 μg/kg, respectively. This method was a simple and efficient method with high sensitivity and precision, and had practical value for the rapid detection of residues of indaziflam and its four metabolites in cereals.
- High performance liquid chromatography-tandem quadrupole-time-of-flight-mass spectrometry,
- Cereals,
- Indaziflam,
- Metabolite
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沈阳化工大学材料科学与工程学院沈阳 110142