Citation: QIAN Zhen-Hua, JIA Wei, LIU Cui-Mei. Analysis of Fragmentation Pathways of Cumyl-Carboxamide Synthetic Cannabinoids New Psychoactive Substances[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(11): 1564-1572. doi: 10.19756/j.issn.0253-3820.201127 shu

Analysis of Fragmentation Pathways of Cumyl-Carboxamide Synthetic Cannabinoids New Psychoactive Substances

1.
Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China;
2.
Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing 100193, China

Corresponding author: LIU Cui-Mei, liucuimei8258@163.com
Received Date: 12 March 2020
Revised Date: 8 September 2020

The aim of this study was to determine the ions formed during the fragmentation of new generation cumyl-carboxamide synthetic cannabinoids using gas chromatography-mass spectrometry (GC-MS) and ultra performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) to identify ions characteristic for different parts of the molecules. Compounds were analyzed on Aglient DB-5MS column (30 m×0.25 mm×0.25 μm) with an initial temperature of 140℃ for gradient increased temperature by GC-MS and Acquity UPLC BEH C₁₈ column (100 mm×2.1 mm i.d., 1.7 μm particle diameter) with 0.1% formic acid aqueous solution (A)-acetonitrile (B) as mobile phase for gradient elution by UPLC-QTOF-MS. The fragmentation behaviors, especially the MS fragmentation rules, were compared and summarized. According to the structure and the typical fragmentations, these compounds could be easily identified. The countless possibilities to create new synthetic cannabinoids by small changes in chemical structures posed a growing challenge to forensic analysts. The work was helpful to assist forensic laboratories in identifying these kinds of compounds or other substances with similar structure in their case work.
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沈阳化工大学材料科学与工程学院沈阳 110142