Citation: LUO Yan-Bo, CHEN Xiao-Jing, LI Xiang-Yu, ZHANG Hong-Fei, ZHU Feng-Peng, JIANG Xing-Yi, PANG Yong-Qiang. Determination of Aldehyde and Ketone Flavor Compounds in Mainstream Smoke of Heated Tobacco Products by Chemical Derivatization-Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(6): 794-801. doi: 10.19756/j.issn.0253-3820.201049 shu

Determination of Aldehyde and Ketone Flavor Compounds in Mainstream Smoke of Heated Tobacco Products by Chemical Derivatization-Liquid Chromatography-Tandem Mass Spectrometry

China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China

Received Date: 19 January 2020
Revised Date: 23 March 2020

Fund Project: This work was supported by the Science Innovation Foundation of China National Tobacco Quality and Supervision & Test Center (No.512018CA0050).

A method for detection of 9 kinds of aldehyde and ketone flavor compounds in mainstream smoke of heated tobacco products based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established. The target analytes in samples and standard solution were derivatized with 1-(2-hydrazinyl-2-oxoethyl)pyridin-1-bromide (Girard reagent P, GP) and d₅-GP, respectively. The derivative products of the standard solution were used as stable isotope internal standards, and the target analytes were analyzed by multiple reaction monitoring mode. The limits of detection were 0.07-12.7 ng/mL under the optimum derivatization conditions. The target analytes exhibited a good linearity with the standard curve correlation coefficients (R²) of not less than 0.9937, and the relative standard deviation was 0.2%-11.6%. The recoveries of real samples at three spiked levels were 82.5%-118.0%. Finally, the method was successfully applied to the analysis of aldehyde and ketone flavor compounds in mainstream smoke of heated tobacco products.
- Chemical derivatization,
- Liquid chromatography-tandem mass spectrometry,
- Heated tobacco product,
- Aldehyde and ketone flavor compounds
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