Citation: FENG Tao-Tao, ZHANG Shuai, ZHANG Li, ZHANG Mei-Ning. Recent Advances on Antifouling of Microelectrode for in Vivo Electrochemistry[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1612-1621. doi: 10.19756/j.issn.0253-3820.191455 shu

Recent Advances on Antifouling of Microelectrode for in Vivo Electrochemistry

Department of Chemistry, Renmin University of China, Beijing 100872, China

Received Date: 28 July 2019
Revised Date: 16 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21874152).

In vivo electrochemistry is one of the attractive approaches for tracking of the dynamic of neurochemicals in the brain. Carbon fiber electrodes (CFE) are usually implanted in specific brain regions for monitoring neurochemicals due to its high spatial and temporal resolution, high sensitivity and small brain tissue damage. However, the implantation of CFE can trigger a series of negative effects for in vivo analysis. On the one hand, protein nonspecific adsorption causes the decrease in electrodes sensitivity. On the other hand, protein-mediated cell adhesion on microelectrode surface can lead to microchemical environment changes around the microelectrode, which affects the accuracy and reliability of the detection results toward neurochemicals. In addition, the resulting fibrous capsule blocks electron transfer between electrode surface and electrolyte, resulting in failure in terms of sensing. In this paper, we briefly introduced the effect of protein adsorption on the electrochemical performance and reviewed the recent advances on antifouling of microelectrode for in vivo electrochemistry.
- In vivo electrochemistry,
- Microelectrode,
- Protein nonspecific adsorption,
- Antifouling,
- Review
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