Citation: WANG Jian-Xing, TIAN Meng, SHU Tong, SU Lei, LIU Guo-Dong, ZHANG Xue-Ji. Electrochemical Sensors Based on Bioreceptors for Detecting Different Conformations of Amyloid-β Peptides[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1492-1501. doi: 10.19756/j.issn.0253-3820.191438 shu

Electrochemical Sensors Based on Bioreceptors for Detecting Different Conformations of Amyloid-β Peptides

1.
Research Center for Biomedical and Health Science, Anhui Science and Technology University, Fengyang 233100, China;
2.
Beijing Advanced Innovation Center of Materials Genome Engineering, Beijing Key Lab for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, Beijing Science and Technology University, Beijing 100083, China;
3.
School of Biomedical Enginering, Shenzhen University, Shenzhen 518055, China

Received Date: 24 July 2019
Revised Date: 2 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21727815) and the Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (No. 20181035).

Alzheimer's disease (AD) has attracted extensive attention because it is a fatal and irreversible progressive neurological disorder and its incidence exponentially increases with age. The early diagnosis of AD has become an urgent prerequisite for its treatment. At present, one of the most important biomarkers for the early diagnosis of AD is amyloid-β peptides (Aβ). Owing to the advantages of electrochemical detection, lots of electrochemical biosensors have been developed for detection of Aβ. In the present review, from the standpoint of Aβ bioreceptors, we summarize the progresses in the electrochemical sensors for detection of Aβ monomers, Aβ oligomers and Aβ fibrils, respectively in the recent five years.
- Alzheimer's disease,
- Early diagnosis,
- Amyloid-β peptides,
- Electrochemical biosensors,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142