Citation: DU Zhan-Hong, LU Yi, WANG Li-Ping. Neurotransmitter Sensing in Diagnosis and Research of Neurological Diseases[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1651-1663. doi: 10.19756/j.issn.0253-3820.191427 shu

Neurotransmitter Sensing in Diagnosis and Research of Neurological Diseases

DU Zhan-Hong ^1,2, ,
LU Yi ^1,2 ,
WANG Li-Ping ^1,2

1.
Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
2.
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China

Received Date: 20 July 2019
Revised Date: 6 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No.31700936), the Science and Technology Planning Project of Guangdong Province (No.2018B030331001), and the Shenzhen Governmental Basic Research Project (No. JCYJ20160531174444711).

Neurotransmitters are critical molecules for nervous system to transmit and modulate information between neurons and other cell types such as glia cells. Measurement of neurotransmitter concentration in vivo can develop and verify numerous novel biomarkers for identifying neurological disorders such as Parkinson's disease, Alzheimer's disease, post-traumatic stress disorder, epilepsy and schizophrenia etc. Meanwhile, in vivo biosensors for neurotransmitters can facilitate neuroscience research in many aspects, such as understanding the basis of cognition, reward, addiction, aversion, learning and memory, as well as the circuitry mechanisms of various neurological disorders. Whilst the in vitro application of neurotransmitter sensors has improved greatly with the advancement of nano materials, microfluidic devices, multielectrode arrays, and many other techniques, in vivo biosensors have not seen many applications in neuroscience field. This review focuses on recent advancement in biosensing techniques for in vitro and in vivo applications. Some techniques use the potential to improve the detection sensitivity and precision of many diseases, and others may be combined with in vivo electrophysiology, optogenetics for improving neural circuitry research. This review also emphasizes novel materials as components of sensors, such as carbon nanomaterials, conducting polymers, aptamers and metal nano-particles.
- Neurotransmitters,
- Biosensors,
- Nanomaterials,
- Imaging,
- Disease diagnosis,
- Review
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