Citation: WANG Jin-Fen, TIAN Hui-Hui, FANG Ying. Implantable and Flexible Electronics for in Vivo Brain Activity Recordings[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1549-1558. doi: 10.19756/j.issn.0253-3820.191411 shu

Implantable and Flexible Electronics for in Vivo Brain Activity Recordings

WANG Jin-Fen ^1,2,5, ,
TIAN Hui-Hui ^1,2 ,
FANG Ying ^1,2,3,4

1.
CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China;
2.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;
3.
University of Chinese Academy of Sciences, Beijing 100049, China;
4.
CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China;
5.
State Key Laboratories of Transducer Technology, Chinese Academy of Sciences, Beijing 100190, China

Received Date: 18 July 2019
Revised Date: 30 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos.21790393, 61971150) and the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDB32030100).

Implantable electronics are essential for electrophysiological recording at single-neuron and sub-millisecond resolution in the fields of neuroscience and neuroprosthesis. Advances in nano/microfabrication techniques offer new and exciting opportunities for the development of high-density implantable electronics. However, the mechanical mismatch between microfabricated rigid electronics and soft brain tissues has been shown to cause inflammatory responses, leading to signal degradation during chronic recording. Recently, flexible electronics with improved mechanical compatibility to brain tissues have been intensively investigated to improve the performance of chronic neural recordings. Flexible electronics can form conformal interfaces with brain tissue, resulting in minimized inflammatory responses and stable signal recordings. In addition, ultra-small, high-density, and multiple-functionality are also desirable features of flexible neural electronics. In this review, we highlight recent progress in microfabricated flexible electronics for in vivo brain activity recordings, with a focus on structural design, brain/tissue interface, implantation method, minimization and multifunctional integration.
- Flexible electronics,
- Implantable electronics,
- Immune reactivity,
- Electrophysiological recording,
- In vivo,
- Review
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