Citation: LI Lin-Yu, WANG Xiao-Ying. Progress in Analysis of Tau Protein[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(6): 685-694. doi: 10.19756/j.issn.0253-3820.191379 shu

Progress in Analysis of Tau Protein

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China

Received Date: 6 July 2019
Revised Date: 18 March 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 81573313, 81302472) and the "Blue Project" Funded by Universities in Jiangsu Province, China.

Tau protein, simply referred to as Tau, is a type of microtubule-associated protein involved in the development of the nervous system. After experiencing conformational changes, abnormal mRNA splicing, etc., Tau dissociates from microtubules and undergoes a series of post-translational modification (PTM) to form pathological aggregation, which induces neurodegenerative diseases and tauopathies eventually. Numerous clinical studies suggest that studying the pathological process of Tau protein, analyzing and evaluating its PTM and quantitative detection of concentration changes are of great significance for the early diagnosis, tracking, prevention and treatment of tauopathies. In this paper, the conventional methods of Tau protein at home and abroad were summarized and compared. Specifically, the related applications and latest research progress of optical and electrochemical biosensors were mainly described. Furthermore, the summary of its future directions and the potential applications were proposed, which provided reference for the further research and application.
- Tau protein,
- Tauopathies,
- Biosensor,
- Post-translational modification,
- Review
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