Citation: HUANG Yan-Yan, ZHAO Rui. Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1629-1638. doi: 10.19756/j.issn.0253-3820.191358 shu

Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides

HUANG Yan-Yan ^1,2, ,
ZHAO Rui ^1,2

1.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 26 June 2019
Revised Date: 4 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21874141, 91853103, 21675161, 21705154) and the Youth Innovation Promotion Association Chinese Academy of Sciences (No. 2015027).

Targeted delivery of molecules and materials across blood-brain barrier (BBB) is critical for in-situ and real-time analysis of central nervous system, which is also a challenge for analytical chemistry. As a kind of endogenous bioactive species, peptides with modulate structure can be designed with predictable conformations and chemically synthesized with high efficiency and purity. Peptides can act as BBB shuttles to transport fluorescent dyes, contrast agents and nanomaterial to target tissues, providing new tools and analytical methods for brain science, disease detection and molecular mechanism investigation. This review summarizes recent advances in analytical applications of BBB shuttle peptides for studying central nervous system. Introduction on BBB, peptides as well as design and screening approaches of BBB shuttle peptides is also included.
- Blood-brain barrier,
- Peptide,
- Targeted analysis,
- Affinity screening,
- Review
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