Citation: WANG Meng, ZHU Li, XIAO Na, JI Cheng-Wei. Investigation of Generation Method of Double Emulsion Broplets Based on Compositional Microfluidic Chip[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(9): 1352-1358. doi: 10.19756/j.issn.0253-3820.191347
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A method was developed for producing double emulsion droplets based on a compositional microfluidic chip that was consisted of a T-micro connector, a cross-micro connector and a glass capillary. T-junction microfluidic chip could fabricate high throughput and uniform oil-in-water (O/W) and water-in-oil (W/O) droplets without hydrophobic or hydrophilic treatments. T-junction microfluidic chip was reusable and highly reliable. The process of generation droplet was simulated by COMSOL in 3D simulation model. The T-junction microfluidic chip was used to generate W/O droplets, and it was found that the high throughput and uniform W/O droplets could be obtained by adjusting the phase flow. Besides, the W/O droplets with different colors were obtained by a microfluidic chip comprised of cross-micro connector and glass capillary. Based on the above experiments, a combination microfluidic chip of T-micro connector, cross-micro connector and glass capillary was constructed. The constructed chip could produce W/O/W double emulsion droplets by adjusting the phase flows. This method offered a simple, low-cost way to produce double emulsion droplets in a short time without professional facilities.
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