Citation: ZHANG Yu, XU Sheng-Wei, HE En-Hui, XIAO Gui-Hua, SONG Yi-Lin, GAO Fei, WANG Mi-Xia, CAI Xin-Xia. Neural Electrostimulation-Detection System and Experimental Validation of Deep Brain Nuclei in Vivo[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1703-1709. doi: 10.19756/j.issn.0253-3820.191312 shu

Neural Electrostimulation-Detection System and Experimental Validation of Deep Brain Nuclei in Vivo

ZHANG Yu ^1,2, ,
XU Sheng-Wei ^1,2 ,
HE En-Hui ^1,2 ,
XIAO Gui-Hua ^1,2 ,
SONG Yi-Lin ^1,2 ,
GAO Fei ^1,2 ,
WANG Mi-Xia ^1,2 ,
CAI Xin-Xia ^1,2

1.
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 30 May 2019
Revised Date: 27 August 2019

Fund Project: This work was supproted by the National Key R&D Program of Nano Science and Technology of China (No. 2017YFA0205902), the National Natural Science Foundation of China (Nos. 61527815, 61601435, 61775216, 61771452), and the Key Research Programs (No. QYZDJ-SSW-SYS015) of Frontier Sciences, Chinese Academy of Sciences.

Although deep brain stimulation (DBS) has become an effective treatment for improving dyskinesia in Parkinson's disease, the exact treatment mechanism remains unclear. In addition, the current system researching DBS mechanism is always composed of two individual parts:the electrical stimulation instrument and the signal detection instrument, which makes it easy to cause the complicated operation of procedure and the waste of resource. In this work, a comprehensive experimental system was established, including an electrostimulation-detection instrument which integrated the function of electrical stimulation and neural signal detection, and the microelectrode arrays (MEA) which were fabricated by micro-electro-mechanical system (MEMS) and modified by nanoplatinum and nafion membrane. Experimental results showed that dopamine in concentration range of 1-50 μmol/L had a good linear relationship with the surface oxidation current of the modified MEA, and the linear correlation coefficient was 0.998. What's more, DBS was designed with the medial forebrain bundle (MFB) as stimulation target and the striatum as detection area, which made the striatal simultaneous observation of dopamine concentration and neuronal firing was achieved while electrical stimulation was applied. Experimental results indicated that the concentration of dopamine in the striatum increased rapidly after stimulation, reaching a maximum of 2.06 μmol/L which was about 1.57 times of the pre-stimulation level; the spike firing rate increased from 1.17 Hz to 6.77 Hz; and the power of local field potential was enhanced from 0.19 mW to 0.64 mW. The electrostimulation-detection system developed in this study realized the integration of electrical stimulation and dual-mode signal detection, which simplified the complex experimental steps and was expected to provide an effective experimental tool for the exploration of DBS treatment mechanism.
- Deep brain stimulation,
- Microelectrode arrays,
- Dopamine,
- Neuro-electrophysiological signal,
- Neurotransmitters
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