Citation: LI Wei-Feng, YAN De-Wen, JIN Yu, LI Hai-Yan, MA Min, WU Zheng-Zhi. Application of Mass Spectrometry in Analysis of Non-Enzymatic Glycation Proteins in Diabetic Blood[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(11): 1732-1741. doi: 10.19756/j.issn.0253-3820.191265 shu

Application of Mass Spectrometry in Analysis of Non-Enzymatic Glycation Proteins in Diabetic Blood

LI Wei-Feng ^1,2, ,
YAN De-Wen ² ,
JIN Yu ² ,
LI Hai-Yan ² ,
MA Min ¹ ,
WU Zheng-Zhi ^1,2,3

1.
Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China;
2.
The First Affiliated Hospital of Shenzhen University, Shenzhen 518020, China;
3.
Shenzhen Institute of Gerontology, Shenzhen 518020, China

Received Date: 8 May 2019
Revised Date: 8 July 2019

Fund Project: This work was supported by the Sanming Project of Medicine in Shenzhen (No. SZSM201612049), the National Natural Science Foundation of China (No. 81574038), and the Shenzhen Discipline Layout Project (No. JCYJ20170412161254416).

Diabetes mellitus is a metabolic disorder disease characterized by hyperglycemia. Long-term physiological environment of hyperglycemia will aggravate the degree of non-enzymatic glycation proteins. Because the abnormal changes of non-enzymatic process will cause a series of pathological changes, non-enzymatic glycation proteins have attracted researchers' attention. Mass spectrometry is an indispensable and powerful analytical tool for qualitative and quantitative analysis of proteins due to its ultra-high sensitivity, excellent detection limit, and multi-component simultaneous analysis, and has been applied to the identification and qualification of non-enzymatic glycation protein. Herein, the principle of non-enzymatic proteins and the research progress of mass spectrometry in the identification and analysis of glycated plasma proteins and hemoglobin in blood were reviewed, and the development trend of this field was prospected.
- Mass spectrometry,
- Non-enzymatic glycation,
- Proteins,
- Diabetes mellitus,
- Review
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