Citation: JIN Wen, LI Fei-Yang, HUANG Yu-Rong, YANG Hui-Wen, CHI Shao-Ming, ZHU Hong-You, LEI Ze, ZHAO Yan. Preparation and Properties Study of Inclusion Complex of Triptonide with 2,6-Dimethyl-β-cyclodextrin[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(8): 1235-1242. doi: 10.19756/j.issn.0253-3820.191112
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The inclusion complex of triptonide (TN) and 2,6-dimethyl-β-cyclodextrin (DM-β-CD) was prepared by saturated aqueous solution method. The TN/DM-β-CD inclusion complex was characterized by FTIR, XRD, SEM, and TG, the possible inclusion mode was inferred by 1H NMR and 2D ROESY. The Job's plot showed that the inclusion ratio of host and guest was 1:1. The stability constant was determined by UV absorbance spectra as 2891 L/mol. The result showed that the DM-β-CD was able to solubilize TN to level as high as 2.7 mg/mL. The water solubility of inclusion complex increased 150 times. In vitro release experiments showed that the cumulative release rate of the inclusion complex reached 70% in 12 h, while the cumulative release rate of TN reached 70% in 120 h. The inclusion complex would have important applications in medical field with higher activity, higher solubility and lower toxicity.
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