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Citation: HUANG Xin, WANG Ni, ZHANG Na, YUE Hao, LIU Shu-Ying. Influence of Process on Ginseng and American Ginseng Property by Neurochemistry Analysis[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(6): 957-963. doi: 10.19756/j.issn.0253-3820.191010 shu

Influence of Process on Ginseng and American Ginseng Property by Neurochemistry Analysis

HUANG Xin ^1, ,
WANG Ni ¹ ,
ZHANG Na ¹ ,
YUE Hao ¹ ,
LIU Shu-Ying ^1,2

1.
Changchun University of Chinese Medicine, Jilin Ginseng Academy, Changchun 130117, China;
2.
Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received Date: 4 January 2019

Fund Project: This work was supported by the National Key R&D Program of the Ministry of Science and Technology of China (No. 2017YFC1702105), the Science and Technology Development Plan Project of Jilin Province, China (No. 20160520181JH) and the Training Plan of Hundreds of Outstanding Treachers of Changchun University of Chinese Medicine (No. 2017086).

On the basis of the neurochemistry analysis, the effects of ginseng, American ginseng, red ginseng and red American ginseng on 24 neurochemicals in rat plasma were investigated by UPLC-QQQ-MS. Combined with chemometrics multivariate statistical analysis, the data were processed by principal component analysis (PCA) and partial least squares discriminant pattern recognition analysis (PLS-DA). By means of the discriminant coefficient and score contribution of recognition model, potential warm and cool properties markers were screened out and the properties difference of ginseng, American ginseng and their processed ones were evaluated. The result showed that 14 kinds of neurochemicals were discovered to be the warm property markers and 10 were cool property markers of ginseng. Among those markers, Glu and Phe presented the most significant effect on warm property, and Gly and 5-HT showed most correlation with cool property. The scores of warm property markers were positive and the corresponding score of red ginseng group was greater than that of ginseng group, demonstrated that the property of red ginseng was warmer than ginseng. For the American ginseng and red American ginseng groups, the scores of cool property markers were positive and cool property of red American ginseng was less than American ginseng. The influence of processing on the property of American ginseng was demonstrated for the first time. The changes of neurochemicals could reflect the influence of warm and cool property on organisms and neurochemistry analysis method could be applied to evaluate the property effect of traditional Chinese medicine. This research provides a methodology reference for the study of the material basis and pharmacological mechanism of the Chinese medicine property difference.
- Neurochemistry,
- Ginseng,
- American ginseng,
- Property
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