Citation: HUANG Ze-Jian, LIU Guang-Cai, JIANG You, LIU Mei-YING, PIAO Yi-Qing, GONG Xiao-Yun, ZHAI Rui, XIE Jie, DAI Xin-Hua, FANG Xiang. Design and Performance Analysis of A Miniature Quadrupole Mass Analyzer[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(7): 985-991. doi: 10.19756/j.issn.0253-3820.181793 shu

Design and Performance Analysis of A Miniature Quadrupole Mass Analyzer

1.
Mass Spectrometry Engineering Technology Research Center, Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China;
2.
College of Instrumentation & Electrical Engineering, Jilin University, Changchun 130061, China;
3.
College of Life Sciences, China JiLiang University, Hangzhou 310018, China

Received Date: 21 December 2018
Revised Date: 6 May 2019

Fund Project: This work was supported by the National Key Research and Development Plan of China(Nos.2017YFF0206204, 2018YFF0212503, 2016YFF0102603, 2012YQ12004907).

For the past two decades, gas chromatography-mass spectrometry (GC-MS), the "gold standard" method, was developed rapidly in terms of the analysis and detection. Among them, the miniaturization of the ion trap mass analyzer developed rapidly, while the quadrupole mass analyzer was relatively slow due to its maximum mass range with the low level. In this work, a small quadrupole mass analyzer with a diameter of 6 mm and a length of 115 mm was designed. Based on this, a small quadrupole mass spectrometer was built and combined with gas chromatography. The test results of mass range, sensitivity, quantitative repeatability and qualitative ability of the instrument proved that the maximum mass range of the miniature quadrupole mass analyzer was more than 500 Th under the unit mass resolution. Based on this miniature quadrupole mass analyzer, the RSD of quantitative reproducibility of perfluoronaphthalene (1 ng) was better than 3%. In the range of 0.1 μg to 0.001 μg, the methamphetamine indicated that the quality and the signal intensity were in the relationship of y=3.19662×10⁷x^1.24606 (R²=0.988). The 16 common drugs at ng level could be accurately identified. The combination of quadrupole mass analyzer and ion pump with wider mass range was expected to enhance the application of small quadrupole mass spectrometer in the field of emergency, drug attack, military counter-terrorism, aerospace and others.
- Gas chromatography-mass spectrometry,
- Quadrupole mass analyzer,
- Miniaturization,
- Drug detection
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