Citation: ZOU Xue-Mei, ZHOU Jia-Wei, SONG Shang-Hong, CHEN Guan-Hua. Screening of Oligonucleotide Aptamers and Application in Detection of Pesticide and Veterinary Drug Residues[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(4): 488-499. doi: 10.19756/j.issn.0253-3820.171539 shu

Screening of Oligonucleotide Aptamers and Application in Detection of Pesticide and Veterinary Drug Residues

College of Food and Bioengineering, Jiangsu University, Zhenjiang 212013, China

Received Date: 31 December 2017
Revised Date: 24 May 2018

Fund Project: This work was supported by the Natural Science Foundation of Jiangsu Province, China (No. BK20151338)

Aptamers are single stranded short deoxyribonucleic acid or ribonucleic acid sequences screened from a random oligonucleotide library that has high affinity and specific recognition for specific target molecules. Since the advent of the systematic evolution of ligands by exponential enrichment (SELEX), there have been various improved screening processes based on SELEX and SELEX or non SELEX selection processes based on capillary electrophoresis separation method. As a molecular recognition element similar to antibody, aptamers have been applied to the detection of residues of pesticide and veterinary drugs closely related to food and environmental safety. In these applications, aptamers usually form composite probes with other materials that can produce signals, such as gold nanoparticles, quantum dots, or constitute sensors with electrochemical electrode. In this paper, the screening methods and the applications of aptamers in the detection of pesticide and veterinary drug residues are summarized, in order to provide a reference for the screening of aptamers and the application in the detection of pesticide and veterinary drug residues.
- Aptamer,
- Screening,
- Pesticide and veterinary drug residues,
- Detection,
- Review
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