Citation: Xu-Liang TAN, Fu-Xing ZHANG, Li-Fang HE, Shi-Yin GUI, Yi-Ling ZHANG, Xiao-Ming ZHU, Liang-Bing SHENG, Yong-Lan FENG, Jiang-Xi YU, Wu-Jiu JIANG. Syntheses, Structures and Anticancer Activities of Two Tri(o-halobenzyl)tin Substituted Benzoates[J]. Chinese Journal of Structural Chemistry, ;2021, 40(5): 675-681. doi: 10.14102/j.cnki.0254–5861.2011–3080 shu

Syntheses, Structures and Anticancer Activities of Two Tri(o-halobenzyl)tin Substituted Benzoates

Department of Chemistry and Materials Science, Hengyang Normal University; Key Laboratory of Functional Metal-organic Complexes of Hunan Province; Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province; Hengyang, Hunan 421008, China

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 25 December 2020
Accepted Date: 16 March 2021

Fund Project: the open fund project of Hunan Provincial innovation platform 18K089the key project of Hunan Provincial education department 19A070the open fund of Hunan Provincial key laboratory M018K07

Figures(5)

Tri(o-chlorobenzyl)tin 2, 4, 6-trimethylbenzoate (1) and tri(o-bromobenzyl)tin salicylate (2) were synthesized and characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C and ¹¹⁹Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The initio calculation and in vitro anticancer activity test were performed for compounds 1 and 2. They are both single tin nucleus structures and the tin atoms were tetracoordinated in a distorted tetrahedral configuration; Compounds 1 and 2 showed stronger anticancer activity than cisplatin in human cervical cancer cells (Hela), liver cancer cells (HuH-7), non-small cell lung cancer cells (A549), lung adenocarcinoma cells (H1975) and breast cancer (MCF-7).
- tri(o-chlorobenzyl)tin 2,
- 4,
- 6-trimethylbenzoate,
- tri(o-bromobenzyl)tin salicylate,
- crystal structure,
- quantum chemistry,
- in vitro antitumor activity
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