Citation: Lei ZHANG, Zhuo CHEN. Research Progress of Structure Based Antitumor Drug Design[J]. Chinese Journal of Structural Chemistry, ;2020, 39(12): 2085-2090. doi: 10.14102/j.cnki.0254–5861.2011–3036 shu

Research Progress of Structure Based Antitumor Drug Design

Lei ZHANG ^{a, b} ,
Zhuo CHEN ^{a, b,,}

a.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Zhuo CHEN, zchen@fjirsm.ac.cn
Received Date: 11 November 2020
Accepted Date: 20 November 2020

Fund Project: the National Natural Science Foundation of China 21877113the National Natural Science Foundation of China 81572944the National Natural Science Foundation of China 31300650Natural Science Foundation of Fujian Province 2020I0036Natural Science Foundation of Fujian Province 2019Y9062Natural Science Foundation of Fujian Province 2013N0039the CAS/SAFEA International Partnership Program for Creative Research Teams 30973567the High-Level Entrepreneurship and Innovation Talents Projects in Fujian Province 2018-8-1

Figures(2)

At present, the development of antineoplastic drugs has been highly concerned. Many strategies have been developed to explore the safety and effectiveness of antitumor drugs. In recent years, the progress of structural analysis of tumor-associated proteins provides a solid foundation for the design of new targeted drugs through efficient prediction and screening technology. In this review, we briefly summarize the research and development of new antitumor drugs based on structure to enhance tumor targeting property and reduce side effects.
- structure,
- drug design,
- antitumor
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