Citation: Jia-Chi XU, Ze-Cheng HU, Ying CUI, Wu-Jiu JIANG, Yu-Xing TAN, Shan-Ji FAN. Syntheses, Crystal Structures and Inhibitory Activity against MCF-7, NCI-H460 and HepG2 Cancer Cells of the Di-2, 4-dichlorobenzyltin Thiophene-2-carbohydrazone Complexes[J]. Chinese Journal of Structural Chemistry, ;2021, 40(6): 827-835. doi: 10.14102/j.cnki.0254–5861.2011–3007 shu

Syntheses, Crystal Structures and Inhibitory Activity against MCF-7, NCI-H460 and HepG2 Cancer Cells of the Di-2, 4-dichlorobenzyltin Thiophene-2-carbohydrazone Complexes

a.
Department of Thyroid Breast Surgery, The First Affiliated Hospital of University South China, Hengyang 421001, China
b.
Hengyang Normal University, Hengyang 421008, China

Corresponding author: Shan-Ji FAN, firear333@hotmail.com
Received Date: 25 October 2020
Accepted Date: 7 January 2021

Fund Project: the Natural Science Foundation of Hunan Province 2020JJ8096

Figures(6)

Di-2, 4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-propanoic carboxylate complex Ⅰ {[C₄H₃S(O)C=N-N=C(CH₃)COO]₂[(2, 4-Cl₂-C₆H₃CH₂)₂Sn]₂(CH₃OH)₂} and di-2, 4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-3-phenylpropanoic carboxylate complex Ⅱ {[C₄H₃S(O)C=N-N=C(PhCH₂)COO](2, 4-Cl₂-C₆H₃CH₂)₂Sn}_n were synthesized and characterized by IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectra, HRMS, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex Ⅰ belongs to monoclinic system, space group P2₁/n with a = 11.987(3), b = 35.359(9), c = 12.982(3) Å, β = 103.028(5)°, Z = 4, V = 5361(2) Å³, D_c = 1. 688 Mg·m^–3, μ(MoKα) = 1.463 mm^–1, F(000) = 2704, R = 0.0572 and wR = 0.1423. The crystal of complex Ⅱ is of monoclinic system, space group P2₁/n with a = 15.5758(17), b = 9.6020(10), c = 19.599(2) Å, β = 98.886(2)°, Z = 4, V = 2896.0(5) Å³, D_c = 1.663 Mg·m^–3, μ(MoKα) = 1.357 mm^–1, F(000) = 1440, R = 0.0341 and wR = 0.0936. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (MCF7, NCI-H460 and HepG2), and they all exhibited good antitumor activity. The interaction between complexes and calf thymus DNA was studied by UV-vis and fluorescence spectroscopy, it indicated intercalation as probable mode of interaction.
- diorganotin,
- carboxylate,
- synthesis,
- crystal structure,
- biological activity
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