Citation: Xu-Min CAI, A-Liang LI, Yu-Ting LIN, Wen-Yan WANG, Shi-Fa WANG, Wen GU. Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid[J]. Chinese Journal of Structural Chemistry, ;2020, 39(8): 1539-1545. doi: 10.14102/j.cnki.0254–5861.2011–2640 shu

Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid

Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Corresponding author: Xu-Min CAI, njguwen@163.com Wen GU, xumin.cai@njfu.edu.cn
Received Date: 15 October 2019
Accepted Date: 8 February 2020

Fund Project: the National Natural Science Foundation of China 31770616the National Natural Science Foundation of China 21601087the Natural Science Foundation for Colleges and Universities in Jiangsu Province 17KJA220002Top-notch Academic Programs Project of Jiangsu Higher Education Institutions PPZY2015C221

Figures(2)

The title compounds (7a~7g) were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS, ¹H- and ¹³C-NMR. The crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system, space group P2₁ with a = 12.282(3), b = 9.940(2), c = 22.656(5) Å, β = 103.06(3)°, Z = 2, V = 2694.4(10) Å³, M_r = 1182.95, D_c = 1.458 Mg/m³, S = 1.000, μ = 1.649 mm^-1, F(000) = 1216, the final R = 0.0791 and wR = 0.1853 for 4098 observed reflections (I > 2σ(I)). The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus (MRSA) with MIC values of 1.9~7.8 μg/mL.
- dehydroabietic acid,
- benzimidazole,
- sulfonamide,
- crystal structure,
- antibacterial activity
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