Citation: Di LI. Anti-lung Cancer Activity and Docking Study of Two Novel Isochroman Derivatives[J]. Chinese Journal of Structural Chemistry, ;2020, 39(5): 901-907. doi: 10.14102/j.cnki.0254–5861.2011–2542 shu

Anti-lung Cancer Activity and Docking Study of Two Novel Isochroman Derivatives

Di LI ^,

Inner Mongolia University for Nationalities, Tongliao 028000, China

Corresponding author: Di LI, di_li45@sina.com
Received Date: 20 July 2019
Accepted Date: 2 December 2019

Fund Project: the Project of Inner Mongolia University for the Nationalities NMDYB15064Science Research Project of Inner Mongolia Education Department NJZY20114

Figures(6)

Two new isochroman derivatives (1 and 2) were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp. 33#. Their structures were characterized by IR, ¹H NMR, H RMS, and single-crystal X-ray crystallography. The anticancer activity of the two compounds was investigated against four human lung cancer cells (NCI-H292, NCI-H460, LTEP-A-2 and MSTO-211) by 3-(4, 5)-dimethylthiahiazo(-z-y1)-3, 5-di-phenytetrazoliumromide (MTT) assay. Furthermore, molecular docking studies supported the biological assay data, showing that compared with 1, compound 2 has stronger interaction with protein.
- isochroman derivatives,
- anticancer activity,
- MTT assay,
- molecular docking
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沈阳化工大学材料科学与工程学院沈阳 110142