Citation: Shan SHU, Fu-Xing ZHANG, Rui-Hai TANG, Shi-Yu YAN, Xiao-Ming ZHU, Liang-Bing SHENG, Dai-Zhi KUANG, Yong-Lan FENG, Jiang-Xi YU, Wu-Jiu JIANG. Syntheses, Structures and Antitumor Activities of Tri(o-bromobenzyl)tin Diethyldithiocarbamate and Tri(m-fluorobenzyl)tin Pyrrolidine Dithiocarbamate[J]. Chinese Journal of Structural Chemistry, ;2020, 39(3): 459-466. doi: 10.14102/j.cnki.0254–5861.2011–2465 shu

Syntheses, Structures and Antitumor Activities of Tri(o-bromobenzyl)tin Diethyldithiocarbamate and Tri(m-fluorobenzyl)tin Pyrrolidine Dithiocarbamate

Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Metal-organic Complexes of Hunan Province; Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Hengyang, Human 421008, china

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 19 May 2019
Accepted Date: 2 September 2019

Fund Project: the Open Fund Project of Innovation Platform Hunan Province Higher Educational Institutions 18K089

Figures(5)

Tri(o-bromobenzyl)tin diethyldithiocarbamate (1) and tri(m-fluorobenzyl)tin pyrrolidine dithiocarbamate (2) have been synthesized and characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C and ¹¹⁹Sn), thermogravimetric analysis and single-crystal X-ray diffraction. The two complexes crystallize in the triclinic system space group P\begin{document}$ \overline 1 $\end{document}. For complex 1, a = 0.9770(1), b = 1.1011(1), c = 1.4583(1) nm, α = 78.431(1)°, β = 86.307(1)°, γ = 69.712(1)°, V = 1.4417(2) nm³, Z = 2, D_c = 1.790 g/cm³, μ(MoKα) = 52.04 cm^–1, F(000) = 756, R = 0.0434 and wR = 0.0593. For complex 2, a = 0.7055(1), b = 1.3349(3), c = 1.3782(3) nm, α = 89.216(2)°, β = 82.044(2)°, γ = 84.637(2)°, V = 1.2799(5) nm³, Z = 2, D_c = 1.537 g/cm³, μ(MoKα) = 11.98 cm^–1, F(000) = 596, R = 0.0313 and wR = 0.0333. The two complexes represent mononuclear structures with five-coordinated [SnC₃S₂] cores forming a distorted trigonal bipyramid. The quantum chemical calculations of 1 and 2 have been investigated. The antitumor activity shows that 1 and 2 have higher activities than cisplatinum against Colo205, HepG2, MCF-7, Hela and H460 cell line in vitro.
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