CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives
- Corresponding author: Jing-Pei CAO, caojingpei@cumt.edu.cn Chang-Jun FENG, fengcj@xzit.edu.cn
Citation:
Hui FENG, Jing-Pei CAO, Chang-Jun FENG. CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives[J]. Chinese Journal of Structural Chemistry,
;2022, 41(3): 220324.
doi:
10.14102/j.cnki.0254-5861.2011-3343
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Ar: 1* = ph, 2 = 4-MeOph, 3 = 2-MeOph, 4 = 3, 4-(OCH2O)ph, 5* = 3, 4, 5-(MeO)3ph, 6 = 4-Meph, 7 = 4-Clph, 8 = 4-Fph, 9 = 4-NO2ph, 10 = 3-NO2ph, 11* = pyridine-4-yl, 12 = pyridine-3-yl, 13 = pyridine-2-yl, 14 = furan-2-yl, 15 = 4-HO2Cph, 16 = 3-HO2Cph, 17* = 4-NCph, 18 = 4-H2NSO2ph, 19* = 2-H2NSO2ph, 20* = 2, 3, 4-(H2NSO2)3ph, 21* = 2, 4-(HO2C)2ph, 22* = 2, 3, 4-(HO2C)3ph Note: (1) "*" represents the compounds in the test set. (2) 19~22 are the newly designed molecules.
(a) pIChp (b) pICca (c) pIChl