Citation: Yue SUN, Zi-Hui YANG, Wen GU. Synthesis, Crystal Structure and Antifungal Activity of New Furan-1, 3, 4-oxadiazole Carboxamide Derivatives[J]. Chinese Journal of Structural Chemistry, ;2022, 41(2): 220209. doi: 10.14102/j.cnki.0254-5861.2011-3232 shu

Synthesis, Crystal Structure and Antifungal Activity of New Furan-1, 3, 4-oxadiazole Carboxamide Derivatives

Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Co-inovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Corresponding author: Wen GU, njguwen@163.com
Received Date: 23 April 2021
Accepted Date: 29 June 2021

Fund Project: the National Natural Science Foundation of China 31770616the Natural Science Foundation for Colleges and Universities in Jiangsu Province 17KJA220002

Figures(3)

A series of novel furan-1, 3, 4-oxadiazole carboxamide derivatives (5a~5e) were designed, synthesized and characterized by spectroscopic methods including HR-MS, ¹H- and ¹³C-NMR. The crystal structure of compound 5a was determined by single-crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P\begin{document}$ \overline 1 $\end{document} with a = 4.7261(5), b = 10.4672(11), c = 14.5886(13) Å, α = 106.081(4)°, β = 91.043(3)°, γ = 99.456(4)°, Z = 2, V = 682.48(12) Å³, M_r = 348.16, D_c = 1.694 Mg/m³, S = 1.008, μ = 3.025 mm^-1, F(000) = 348, the final R = 0.0775 and wR = 0.2080 for 2774 observed reflections (I > 2σ(I)). There are two kinds of hydrogen bonds (N(3)–H(3A)⋅⋅⋅N(2) and C(8)–H(8A)⋅⋅⋅O(3)) present in its crystal structure. The preliminary antifungal assay showed that compounds 5b and 5c exhibited significant antifungal activities against several plant pathogenic fungi.
- furan-1, 3, 4-oxadiazole carboxamide,
- synthesis,
- crystal structure,
- antifungal activity
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