Citation: Xu WANG, Fei DONG, Wen-Feng HAO, Xu-Kai ZHOU, Kai-Yun CHEN, Jin-Ping FU. Synthesis, Crystal Structures and Antioxidant Activities of 1,5-Diketone Derivatives[J]. Chinese Journal of Structural Chemistry, ;2020, 39(9): 1655-1661. doi: 10.14102/j.cnki.0254-5861.2011-2757 shu

Synthesis, Crystal Structures and Antioxidant Activities of 1,5-Diketone Derivatives

College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China

Corresponding author: Xu WANG, wangxu504@126.com Jin-Ping FU, fujinping2012@163.com
Received Date: 5 February 2020
Accepted Date: 15 February 2020

Fund Project: the Youth Promotion Fund of Guangxi 2019KY0386Guangxi Science and Technology Base and Talents Program AD19110109Guangxi University of science and Technology Foundation 197309

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A new transition-metal-free protocol for the synthesis of polysubstituted 1,5-diketone derivatives from readily available starting materials has been developed. All the compounds were confirmed by HRMS, ¹H NMR and ¹³C NMR, and the single crystal structure of compound 4f was determined to be of triclinic system, space group P\begin{document}$ \overline 1 $\end{document} with a = 8.6515(8), b = 8.6694(10), c = 12.4985(8) Å, β = 102.152(6)°, V = 895.43(15) Å³, D_c = 1.625 g/cm³, Z = 2, F(000) = 436, μ(MoKα) = 1.807 mm^-1, R = 0.0342 and wR = 0.0691. Furthermore, the result of antioxidation test demonstrated that compound 4a exhibited better antioxidant activity than butylated hydroxytoluene and vitamin C by the ABTS⁺ radical cation decolorization assay. In addition, we further studied the mechanism of the transition-metal-free catalytic multicomponent domino reaction.
- 1,5-diketones,
- synthesis,
- single crystal structure,
- antioxidant activity
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