Citation: Di LI. Synthesis, Anti-lung Cancer Activity and Docking Study of New Organic Compounds[J]. Chinese Journal of Structural Chemistry, ;2020, 39(6): 1119-1125. doi: 10.14102/j.cnki.0254-5861.2011-2558 shu

Synthesis, Anti-lung Cancer Activity and Docking Study of New Organic Compounds

Di LI ^,

Inner Mongolia University for Nationalities, Tongliao 028000, China

Corresponding author: Di LI, di_li45@sina.com
Received Date: 1 August 2019
Accepted Date: 3 December 2019

Fund Project: the Project of Inner Mongolia University for the Nationalities NMDYB15064Science Research Project of Inner Mongolia Education Department NJZY20114

Figures(5)

Novel organic compounds (1~8) were designed, synthesized and characterized by IR, ¹H NMR, H RMS, and single-crystal X-ray crystallography. The anticancer activities of these compounds were investigated against four human lung cancer cells (H20, H2227, H69 and H524) by 3-(4, 5)-dimethylthiahiazo(-z-y1)-3, 5-di-phenytetrazoliumromide (MTT) assay. Furthermore, by taking compounds 1 and 5 as representatives, molecular docking studies supported the biological assay data, suggesting that compared with 1, compound 5 has stronger interaction with protein.
- MTT assay,
- anticancer activity,
- molecular docking
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沈阳化工大学材料科学与工程学院沈阳 110142