Citation: Hua-Lin CHEN, Qi-Tong HUANG, Shi-Rong HU, Shu-Li TANG, Hao YANG, Zhan-Ming LI. Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum[J]. Chinese Journal of Structural Chemistry, ;2020, 39(6): 1035-1043. doi: 10.14102/j.cnki.0254-5861.2011-2529 shu

Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

Hua-Lin CHEN ^a ,
Qi-Tong HUANG ^b ,
Shi-Rong HU ^a,, ,
Shu-Li TANG ^a ,
Hao YANG ^a ,
Zhan-Ming LI ^{c, d}

a.
College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou 363000, China
b.
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China
c.
Department of Food Science, China Jiliang University, Hangzhou 310018, China
d.
Food Science and Technology Programme, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore

Corresponding author: Shi-Rong HU, hushirong6666@163.com
Received Date: 2 July 2019
Accepted Date: 23 October 2019

Fund Project: the Education Bureau of the Fujian province projects JAT160302the Natural Science Foundation of Zhejiang province LQ17C200002the Talents' Start-up Fund of Gannan Medical University projects QD201825

Figures(9)

In this paper, we present a novel, reliable and sensitive electrochemical sensor for the determination of paracetamol based on hollow carbon Co₃O₄ nanosheets/reduced graphene oxide composite (Co₃O₄/r-GO). The Co₃O₄/r-GO was prepared via a rapid one-step microwave solvothermal process. Some series of techniques that included scanning electron microscopy, X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials. Most importantly, the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0 μM and a low detection limit of 14.0 nM (S/N = 3) by using differential pulse voltammetry. Furthermore, the selectivity, repeatability, stability and practical applicability were further studied with satisfactory results.
- Co₃O₄ nanosheets,
- reduced graphene oxide,
- paracetamol,
- electrochemical sensor
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Co3O4/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

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Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum