Citation: YUAN Lin, LI Zhong-Yan, ZHANG Min, YUAN Xian-You. Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine[J]. Chinese Journal of Structural Chemistry, ;2016, 35(8): 1181-1185. doi: 10.14102/j.cnki.0254-5861.2011-1127 shu

Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine

1.
Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China

Received Date: 13 January 2016
Available Online: 14 April 2016
Fund Project:

The title compound 2-(4-chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine (C₁₉H₁₇ClN₂) was synthesized and characterized by elemental analysis, ¹H NMR, HRMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to orthorhombic system, space group Pnma with a=11.385(2), b=12.170(2), c=11.210(2)Å, V=1553.2(5)Å³, Z=4, D_c=1.321 g/cm³, μ(Mo-Kα)=0.244 mm^-1, F(000)=648, S=1.309, R=0.0400 and wR (I>2σ(I))=0.1065. X-ray diffraction results showed that the molecular structure is highly symmetric and the new-formed N-heterocyclic ring is non-planar. In addition, the biological experiment showed that the title compound showed inhibitory activities against fungi with varied potencies.
- perimidine,
- synthesis,
- crystal structure,
- biological activity
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