Citation: TIAN Lai-Jin, YAO Yan-Ze, LIU Qing-Tao, ZHENG Xiao-Feng. Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine[J]. Chinese Journal of Structural Chemistry, ;2016, 35(6): 849-856. doi: 10.14102/j.cnki.0254-5861.2011-1058 shu

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

1.
Department of Chemistry, Qufu Normal University, Qufu 273165, China

Corresponding author: TIAN Lai-Jin,
Received Date: 20 November 2015
Available Online: 29 January 2016
Fund Project: the Research Award Fund for Outstanding Young Scientists in Shandong Province (BS2014CL015) (ZR2013BM007)

Three cyclohexyltin complexes of N-(3,5-dibromosalicylidene)valine (H₂L), Cy₃Sn(HL) (1), Cy₂SnL (2), and Cy₂SnL·Cy₃SnCl (3) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and ¹H and^{13C NMR spectra.}The crystal structures of 2 and 3 have been determined. Complex 2 belongs to the monoclinic system, space group P2₁/n with a = 21.250(8), b = 10.837(4), c = 23.050(8) Å, b = 93.193(9)°, V = 5300(3) Å³, Z = 8, D_c= 1.659 g/cm³, m ＝ 4.004 mm^-1, F(000) = 2624, R = 0.0471 and wR = 0.1015. Complex 3 belongs to the monoclinic system, space group P2₁ with a = 10.3452(10), b = 18.7665(18), c = 12.1483(12) Å, b = 103.374(2)°, V = 2294.5(4) Å³, Z = 2, D_c= 1.542 g/cm³, m = 2.923 mm^-1, F(000) = 1072, R = 0.0428 and wR = 0.0936. Complex 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand, and 3 reveals that the two tin atoms are joined via the carbonyl atom of the ligand to form a mixed organotin binuclear complex. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli.
- organotin complex,
- N-(3,5-dibromosalicylidene)valine,
- crystal structure,
- antibacterial activity
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沈阳化工大学材料科学与工程学院沈阳 110142