Citation: WANG Fang-Ming, HU Bing-Xiang, CHEN Chuan-Xiang, ZHOU Ze-Yu, BAO Dan, CHEN Li-Zhuang. Synthesis and Biological Activities of 10-Substituted 9-Aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones[J]. Chinese Journal of Structural Chemistry, ;2016, 35(3): 442-448. doi: 10.14102/j.cnki.0254-5861.2011-0915 shu

Synthesis and Biological Activities of 10-Substituted 9-Aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones

1.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China

Corresponding author: WANG Fang-Ming,
Received Date: 28 July 2015
Available Online: 9 November 2015
Fund Project: This project was supported by National Natural Science Foundation of China for Young Scholars (No. 21201087) (No. 21201087)

A series of 10-substituted 9-aryl-3, 4, 6, 7, 9, 10-hexahydroacridine-1, 8(2H, 5H)-dione derivatives 2 were synthesized by a two-step reaction. All the compounds were characterized by IR, MS, and ¹H NMR. Crystals of 1a and 2c were obtained and determined by X-ray single-crystal diffraction. Crystal data of 1a: C₂₀H₂₂O₅, orthorhombic system, space group Pbcn, a = 15.8888(19), b = 18.228(2), c = 11.6926(13) Å, V = 3386.4(7) Å³, Z = 8, F(000) = 1456, D_c = 1.343 g/cm³, R = 0.0456 and wR = 0.1600. Crystal data of 2c: C₂₆H₂₄ClNO₃, monoclinic system, space group P2₁/n, a = 8.628(2), b = 10.912(3), c = 22.425(7) Å, β = 90.786(4)°, V = 2111.1(10) Å³, Z = 4, F(000) = 912, D_c = 1.365 g/cm³, R = 0.0613, and wR = 0.1196. The results of biological experiments show that compounds 2b and 2c could inhibit the proliferation of HepG2 cells.
- xanthenes,
- acridones,
- synthesis,
- crystal structure,
- biological activity
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