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Citation: ZHU Xiao-Ming, KUANG Dai-Zhi, FENG Yong-Lan, ZHANG Fu-Xing, YU Jiang-Xi, JIANG Wu-Jiu, ZHANG Zhi-Jian. Synthesis, Crystal Structure, Thermal Stability and Anti-tumor Activity In Vitro of Bis(tricyclohexyltin) Pimelicarboxylate[J]. Chinese Journal of Structural Chemistry, ;2015, 34(11): 1652-1658. doi: 10.14102/j.cnki.0254-5861.2011-0779 shu

Synthesis, Crystal Structure, Thermal Stability and Anti-tumor Activity In Vitro of Bis(tricyclohexyltin) Pimelicarboxylate

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a. Department of Chemistry and Material Science, Hengyang Normal University; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan;
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b. Department of Life Science, Hengyang Normal University, Hengyang 421008, Hunan

Received Date: 22 April 2015
Available Online: 15 September 2015
Fund Project: Supported by the Natural Science Foundation of Hunan Province (No. 13JJ3112) (No. 13JJ3112) Scientific & Technological Projects of Hunan Province (Nos. 2013TZ2025, 2014NK3086, 2014FJ3060) (Nos. 2013TZ2025, 2014NK3086, 2014FJ3060) the Open Fund Project of Key Laboratory of Functional Organometallic Materials of Hengyang Normal University (Nos. 13K105, 14K014, 13K01-05, GN14K01) (Nos. 13K105, 14K014, 13K01-05, GN14K01)the Science Foundation of Hengyang Normal University of China (No. 12C45) (No. 15C0199, 15C0200, 14C0171, 14C0168)

Bis(tricyclohexyltin) pimelicarboxylate, [(CH₂)₅(CO₂SnCy₃)₂] (1), has been synthesized by the reaction of tricyclohexyltin hydroxide with pimelic acid and characterized by means of IR, ¹H and ¹³C NMR, elemental analysis and X-ray diffraction. Complex 1 crystallizes in triclinic space group P1 with a=11.569(3), b=12.0419(2), c=17.3988(4) Å, α=81.4310(10), β=79.8270(10), γ=69.7060(10)°, V=2227.60(9) Å³, Z=2, C₄₃H₇₆O₄Sn₂, M_r=894.42, D_c=1.333 g·cm^-3, μ=1.157 mm^-1, F(000)=932, GOOF=1.339, the final R=0.0452 and wR=0.1333 for 6709 observed reflections (I>2σ(I)). Complex 1 shows discrete dimeric structures and the tin atoms have a distorted tetrahedral geometry. The 1D chain structure of complex 1 is formed by intermolecular Sn…O interactions. Complex 1 displays good thermal stability under 553 K and has selective antibacterial property. Complex 1 is strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and is significantly higher than that in the clinical use of carboplatin.
- tricyclohexyltin pimelicarboxylate,
- synthesis,
- crystal structure,
- biological activity
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