Citation: MA Yu-Heng, GE Shu-Wang, SUN Bai-Wang. Synthesis, Characterization and Theoretical Studies of a Novel Salt (Dexmedetomidine: Perchloric Acid=1:1) and the Investigation of Its Stability[J]. Chinese Journal of Structural Chemistry, ;2015, 34(8): 1179-1186. doi: 10.14102/j.cnki.0254-5861.2011-0700 shu

Synthesis, Characterization and Theoretical Studies of a Novel Salt (Dexmedetomidine: Perchloric Acid=1:1) and the Investigation of Its Stability

1.
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China

Corresponding author: SUN Bai-Wang,
Received Date: 3 March 2015
Available Online: 11 June 2015
Fund Project: This work was supported by the prospective joint research project of Jiangsu province (BY20122193) (BY20122193)the Fundamental Research Funds for the Central Universities (CXZZ12_0119) (CXZZ12_0119)

Dexmedetomidine and its novel salt have been synthesized and characterized by single-crystal XRD and TGA/DSG. Components of the crystalline phase have also been investigated in terms of their corresponding Hirshfeld surface. In the crystal lattice, a three-dimensional hydrogen-bonded network is observed. In this work, the salt strategy has been applied successfully to dexmedetomidine. One important parameter, i.e. stability, has also been significantly improved, which proves to be an important factor for solid dosage formulation. Furthermore, DSC/TGA analysis indicates that the salt maintains its crystallinity up to 300℃, suggesting a higher stability of the salt compared to pure dexmedetomidine.
- single-crystal X-ray diffraction,
- DSC/TGA,
- crystal structure,
- hydrogen bond,
- Hirshfeld surfaces
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