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Citation: HE Chuan-Chuan, LI Yue, ZHAO Jing, XU Guan-Cheng, SUN Su-Rong. Synthesis, Crystal Structure and Biological Properties of One Zinc(Ⅱ) Complex Based on 4-Acyl Pyrazolone Derivative[J]. Chinese Journal of Structural Chemistry, ;2015, 34(7): 1019-1027. doi: 10.14102/j.cnki.0254-5861.2011-0648 shu

Synthesis, Crystal Structure and Biological Properties of One Zinc(Ⅱ) Complex Based on 4-Acyl Pyrazolone Derivative

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a. Key Laboratory of Material and Technology for Clean Energy, Ministry of Education, Key Laboratory of Advanced Functional Materials, Autonomous Region, Institute of Applied Chemistry, Xinjiang University, Urumqi 830046, China;
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b. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China

Received Date: 25 January 2015
Available Online: 6 May 2015
Fund Project: Supported by the National Science Foundation of China (No. 21161019, 21301146) (No. 21161019, 21301146) Natural Science Fund for Distinguished Young Scholars of Xinjiang Uygur Autonomous (No. 2013711008) (No. 2013711008)Technological Innovation Youth Training Project of Xinjiang Autonomous (No. 2013721017) (No. 2013721017)

[Zn(L)(CH₃OH)₃] (H₂L=N-(1-phenyl-3-methyl-4-propenylidene-5-pyrazolone)-salicylidene hydrazide) has been synthesized by the reaction of zinc nitrate and ligand H₂L. The complex crystallizes in orthorhombic system, space group Pbca with a=5.888(15), b=14.564(14), c=22.20(2)Å, V=5137(8)Å³, Z=8 and F(000)=2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc(Ⅱ) atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide (EB) displacement experiments. The results showed that the DNA-binding constant of the complex is 5.1×10⁴M^-1. Antitumor activity of [Zn(L)(CH₃OH)₃] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and HeLa than free ligand.
- zinc(Ⅱ) complex,
- 4-acyl pyrazolone derivative,
- crystal structure,
- DNA-binding,
- antitumor activity
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