Citation: LIU Wen-Qian, ZHOU Shi-Lei, FAN Ming-Zhu, PAN Zhi-Quan, CHEN Yun-Feng. Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex Based on a Carboxyl-substituted 1H-1,2,3-Triazole and Its DNA Cleavage Activity[J]. Chinese Journal of Structural Chemistry, ;2015, 34(6): 917-924. doi: 10.14102/j.cnki.0254-5861.2011-0634 shu

Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex Based on a Carboxyl-substituted 1H-1,2,3-Triazole and Its DNA Cleavage Activity

1.
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, China

Received Date: 13 January 2015
Available Online: 25 March 2015
Fund Project: This work was supported by the National Natural Science Foundation of China (No.21002076) (No.21002076)

The novel dinuclear copper complex [Cu₂(H₂O)₂(DMF)₂(L)₂] (1, H₂L=5-phenyl-2H-1,2,3-triazole-4-carboxylic acid, DMF=N,N-dimethyl-formamide) has been synthesized and characterized by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P1 with a=9.591, b=10.508, c=15.515 Å, β=75.11°, V=1446.2 Å³, Z=2, M_r=683.62, D_c=1.570 g/cm³, μ=1.531 mm^-1, F(000)=700, the final R=0.0404 and wR=0.1130 for 5327 observed reflections with I>2σ(I). In each unit of the complex, two Cu²⁺ ions coordinated with two triazole ligands to form a dimeric [5,6,5] tricyclic structure. The central Cu atom is five-coordinated, and each copper atom shows a square pyramidal geometry. The crystal structure is stabilized by the inversion-related O-H···O hydrogen bond and C-H···O hydrogen bonding interactions to form a layer structure. Fluorescent spectra show an obvious quenching of fluorescence compared with free 1,2,3-triazole ligand. The results of agarose gel electrophoresis indicate that this complex can cleave the plasmid supercoiled DNA within shorter time in the 50-folds excess of ascorbate under physiological conditions, providing a new example in the research for artificial metal nucleic acid enzyme.
- 1,2,3-triazole,
- copper complex,
- crystal structure,
- fluorescent property,
- DNA cleavage activity
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