Citation: ZHAO Pei-Liang, HU Meng-Jin, DUAN An-Na, SUN Xiao-Min, YOU Wen-Wei. Synthesis, Crystal Structure and Antitumor Activity of 2-(3-Methyl-5-(methylthio)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione[J]. Chinese Journal of Structural Chemistry, ;2015, 34(3): 359-364. doi: 10.14102/j.cnki.0254-5861.2011-0513 shu

Synthesis, Crystal Structure and Antitumor Activity of 2-(3-Methyl-5-(methylthio)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione

a.
a. Department of Chemistry, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;
b.
b. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

Received Date: 17 September 2014
Available Online: 12 November 2014
Fund Project:

The title compound 2-(3-methyl-5-(methylthio)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione (C₁₂H₁₀N₄O₂S, M_r=274.30) has been synthesized by a three-step procedure including the cyclization, hydrazinolysis and substitution reactions, and its crystal structure was determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2₁/c with a=12.264(3), b=14.646(3), c=14.349(4)Å, β=91.69(3)°, μ=0.255 mm^-1, M_r=274.30, V=2576.2(10)Å³, Z=8, D_c=1.414 g/cm³, F(000)=1136, R=0.0487 and wR=0.1329 for 4048 observed reflections with I>2σ(I). In addition, the preliminary bioassay suggested that the title compound 6 exhibits relatively good antitumor activity against HT-29 and MCF-7.
- 2-(3-methyl-5-(methylthio)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione,
- synthesis,
- crystal structure,
- antitumor activity
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