Citation: CUI Yong-Mei, LIU Xin-Lan, WANG He-Yun, LIN Hai-Xia. Syntheses and Crystal Structures of 12-Oxime Dehydroabietic Acid Derivatives[J]. Chinese Journal of Structural Chemistry, ;2015, 34(1): 69-76. doi: 10.14102/j.cnki.0254-5861.2011-0445 shu

Syntheses and Crystal Structures of 12-Oxime Dehydroabietic Acid Derivatives

1.
Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China

Corresponding author: CUI Yong-Mei,
Received Date: 7 July 2014
Available Online: 15 September 2014
Fund Project:

Three novel dehydroabietate oxime derivatives were synthesized from dehydro-abietic acid and their crystal structures were determined by X-ray crystallographic techniques. All of these 12-oxime dehydroabietic acid derivatives crystallize in orthorhombic system, space group P2₁2₁2₁. In the structures, rings A and B exhibit chair and half-chair configurations, respectively and form trans ring junction with two methyl groups (C(19) and C(20)) in the axis positions. The oxime groups have E conformations. Comparison of conformations reveals subtle differences principally in ring B due to the modification in C(12). The E-acetaldehyde oxime derivative 2c showed distinct BKα gate-opening activity with an ionic current increase of 164% at 30 μM versus the control current.
- crystal structure,
- conformation,
- dehydroabietic acid,
- oxime,
- BKα channel
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