Citation: SUN Zhao-Hui, ZAI Zhi-Wen, YANG Ming-Yan, LIU Xing-Hai, TAN Cheng-Xia, WENG Jian-Quan. Microwave Assistant Synthesis and Dimeric Crystal Structure of 2-(((6-Chloropyridin-3-yl)-methyl)thio)-5-(pyridin-4-yl)-1,3,4-thiadiazole[J]. Chinese Journal of Structural Chemistry, ;2014, 33(12): 1779-1783. doi: 10.14102/j.cnki.0254-5861.2011-0380 shu

Microwave Assistant Synthesis and Dimeric Crystal Structure of 2-(((6-Chloropyridin-3-yl)-methyl)thio)-5-(pyridin-4-yl)-1,3,4-thiadiazole

1.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China

Received Date: 19 May 2014
Available Online: 18 June 2014
Fund Project: This work was funded by the National Natural Science Foundation of China (No. 21002090) (No. 21002090) and the National Key Technologies R&D Program (2011BAE06B03-01) (2010R50018-06)

The title compound 2-(((6-chloropyridin-3-yl)methyl)thio)-5-(pyridin-4-yl)-1,3,4-thiadiazole 5 (C₂₆H₁₈Cl₂N₈S₄) was synthesized, and its structure was confirmed by ¹H NMR, MS and elemental analyses and X-ray diffraction. It crystallizes in the triclinic system, space group P1, with a=9.452(4), b=12.335(4), c=13.017(5)Å, α=90.624(5), β=110.541(5), γ=104.879(4)°, D_c=1.561 g/cm³, Z=2, V=1364.9(9)Å³, F(000)=656, the final R=0.0300 and wR=0.0635 for 4206 observed reflections with I>2σ(I). The preliminary biological test showed that the title compound has activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory activities to be 9.82%, 44.44% and 20.00%, respectively.
- 1,3,4-thiadiazole,
- pyridine,
- synthesis,
- crystal structure,
- fungicidal activities
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