酶定向进化实现有机硅化合物转化

引用本文: 陈烨荣, 杨冰彬, 何星磊, 林雨琦, 叶克印. 酶定向进化实现有机硅化合物转化[J]. 大学化学, 2025, 40(10): 121-129. doi: 10.12461/PKU.DXHX202411054 shu

Citation: Yerong Chen, Bingbin Yang, Xinglei He, Yuqi Lin, Keyin Ye. Enzyme-Directed Evolution Enables Bioconversion of Organosilicon Compounds[J]. University Chemistry, 2025, 40(10): 121-129. doi: 10.12461/PKU.DXHX202411054 shu

酶定向进化实现有机硅化合物转化

福州大学化学学院, 福州 350108
基金项目:
教育部 2022 年度基础学科拔尖计划 2.0 研究课题(20222114)

福州大学研究生院本博贯通培养教改项目(0480/00489075)

摘要: 有机硅化合物由于其特殊的物理化学性质，在诸如电子、材料及医药等多个领域得到了广泛应用。然而，由于生物系统在自然条件下通常难以合成与转化大多数有机硅化合物，传统上这些化合物的合成与转化主要依赖于化学方法。2018年诺贝尔化学奖得主Frances H. Arnold教授及其课题组通过酶定向进化，成功实现了对这些非天然合成物的生物催化转化。本文详细回顾了该课题组在有机硅化合物的合成与转化方面的研究进展，梳理其反应机制与相关应用，旨在增进对该领域的理解，并推动生物催化的进一步研究。

关键词:

English

Enzyme-Directed Evolution Enables Bioconversion of Organosilicon Compounds

College of Chemistry, Fuzhou University, Fuzhou 350108, China
Received Date: 19 November 2024
Revised Date: 11 February 2025
Available Online: 22 April 2025

Abstract: Owing to their unique physicochemical properties, organosilicon compounds have found widespread applications in various fields such as electronics, materials science, and pharmaceuticals. However, biological systems typically cannot synthesize or convert most organosilicon compounds under natural conditions, making chemical methods the conventional approach for their synthesis and transformation. In a landmark achievement, Professor Frances H. Arnold, recipient of the 2018 Nobel Prize in Chemistry, and her research team successfully achieved biocatalytic conversion of these non-natural compounds through enzyme-directed evolution. This review systematically examines the team’s research progress in organosilicon compound synthesis and transformation, analyzes the underlying reaction mechanisms, and discusses relevant applications. Our aim is to enhance understanding in this field and facilitate further research in biocatalysis.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

酶定向进化实现有机硅化合物转化

English

Enzyme-Directed Evolution Enables Bioconversion of Organosilicon Compounds

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

酶定向进化实现有机硅化合物转化

English

Enzyme-Directed Evolution Enables Bioconversion of Organosilicon Compounds

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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