Abstract: This paper presents an overview of the teaching design and considerations for the chapter on “osmotic pressure of solutions” in medical chemistry courses. The chapter covers topics such as osmotic phenomena, osmotic concentration, the calculation of solution osmotic pressure, and its applications in medicine. The calculation of osmotic concentration and osmotic pressure presents significant challenges for most students. To address this, the teaching design is centered on a problem-based approach, incorporating real-life phenomena and case studies. The instructional sequence includes creating problem scenarios, experimental exploration, computational derivation, knowledge transfer and application, knowledge extension, and integrating ideological and political education. By weaving computational examples and medical case studies throughout the course, the problem-oriented teaching approach enhances student engagement and helps them grasp the key concepts and content of the chapter during classroom instruction, ultimately achieving the teaching objectives.