Abstract: As one of the 12 core courses of the Chemistry “101 Plan”, synthetic chemistry experiment is designed as a through-type, full-chain experimental course for undergraduates majoring in chemistry and related fields, covering topics from basic synthesis to advanced synthesis and comprehensive synthesis. Unlike traditional teaching modes that separate experimental courses by secondary disciplines, this course restructures the experimental knowledge system around synthetic methods. It integrates the synthesis of inorganic, organic, polymeric, supramolecular substances, and applied materials to establish a complete methodology of synthetic chemistry. The course content balances fundamental and cutting-edge experiments, emphasizing interdisciplinary connections and knowledge integration. By designing comprehensive experiments across the full chain—including preparation and synthesis, separation and purification, structure and characterization, reaction and performance, and materials and applications—the course aims to help students strengthen the integration of knowledge and skills, fostering their scientific thinking and innovative consciousness. This article briefly outlines the reform ideas and construction of the synthetic chemistry experiment, addressing aspects such as course orientation, goals, design concepts, core knowledge systems, textbook/lesson plans, and the teaching team.