Abstract: To address the inherent challenges of extensive theoretical complexity in organic chemistry education and its insufficient integration with agricultural and forestry disciplines, we developed the value-driven O-VALUE innovation model. This comprehensive approach features three core components: 1) Restructured instructional content organized into thematic modules that present chemical solutions to agriculture-forestry challenges; 2) Enhanced pedagogical strategies employing problem-based seminars, practical case analyses, and immersive four-month agricultural research projects; 3) Enriched curriculum resources building upon national first-class online courses, emphasizing “structure-property-function” chemical reasoning complemented by SPOC modules for professional competency development. The evaluation system incorporates chemical thinking applications in agriculture-forestry problem-solving as key ideological assessment metrics. Through systematic implementation, this reform transforms the omnipresent chemical principles in interdisciplinary studies into engaging learning experiences, while translating chemistry's versatile applications into professional commitments for life sciences and agricultural advancement. Empirical results demonstrate enhanced student competencies in addressing plant protection, food security, pharmaceutical development, and sustainable resource utilization, significantly improving learning outcomes and professional motivation.