化学“101计划”——化学生物学教材设计与建设

引用本文: 刘扬, 陈鹏, 刘磊. 化学“101计划”——化学生物学教材设计与建设[J]. 大学化学, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085 shu

Citation: Yang Liu, Peng Chen, Lei Liu. Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook[J]. University Chemistry, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085 shu

化学“101计划”——化学生物学教材设计与建设

刘扬 ^1, ,
陈鹏 ^2, ,
刘磊 ^1,

1.
清华大学化学系, 生命有机磷及化学生物学教育部重点实验室, 北京 100084;
2.
北京大学化学与分子工程学院, 生物有机与分子工程教育部重点实验室, 北京 100871
基金项目:
高等教育质量保障专项(化学“101计划”专项)

摘要: 化学生物学是化学“101计划”所布局建设的12门核心课程之一。作为一门研究生命进程当中化学本质与分子基础的前沿交叉学科，化学生物学涉及领域范畴广，知识跨度大；而伴随着化学生物学前沿的不断发展，如何建立系统的课程体系并兼顾不同专业学生的学习需求，为教材的设计建设提出了更高要求。为此，教材编者们通过调研比较不同化学生物学教材内容及课程设计，梳理总结化学生物学教材模块及知识点；从化学生物学的分子基础、核心技术及前沿应用三个方面，建立从理论到应用、从基础到前沿的化学生物学教学框架；在知识融合、内容深度、实践导向等方面展示创新特色。以交叉学科的发展和国家战略需求为出发点，力求呈现一本化学与生命科学、医学交叉融合的新型化学生物学教材，为学生带来兼具挑战性和启发性的学习体验。

关键词:

English

Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook

1.
Department of Chemistry, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, China;
2.
Key Laboratory of Bioorganic Chemistry & Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Received Date: 22 July 2024
Revised Date: 10 September 2024
Available Online: 19 September 2024

Abstract: Chemical biology is one of the 12 core courses developed under the “101 Plan” for chemistry. As an emerging interdisciplinary field that explores the chemical basis and molecular foundations of life processes, chemical biology encompasses a broad range of topics and extensive knowledge. With ongoing advancements in the field, establishing a systematic curriculum that addresses the diverse needs of students from various disciplines presents a significant challenge for textbook design and construction. To address this, the authors have investigated and compared the content and curriculum design of different chemical biology textbooks, summarized the key modules and knowledge areas, and developed a teaching framework based on three main aspects: the molecular basis of chemical biology, core technologies, and applications. The textbook aims to showcase innovative features in knowledge integration, content depth, and practical orientation. By aligning with the development of interdisciplinary subjects and national strategic needs, the textbook seeks to provide a cross-disciplinary integration of chemistry, biology, and medicine, offering students a challenging and insightful learning experience.

Key words:

1. [1]
  图解! 这就是“101计划”. [2024-04-20]. http://www.moe.gov.cn/jyb_xwfb/s7600/202404/t20240422_1126838.html
2. [2]
  刘磊, 陈鹏, 赵劲, 何川. 化学生物学基础. 北京: 科学出版社, 2010.
3. [3]
  Hang, H. C.; Pratt, M. R.; Prescher, J. A. Advanced Chemical Biology-Chemical Dissection and Reprogramming of Biological Systems; Wiley-VCH: Weinheim, Germany, 2023.Hang, H. C.; Pratt, M. R.; Prescher, J. A. Advanced Chemical Biology-Chemical Dissection and Reprogramming of Biological Systems; Wiley-VCH: Weinheim, Germany, 2023.
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  Vranken, D. V.; Weiss, G. A. Introduction to Bioorganic Chemistry and Chemical Biology; Garland Science: New York, NY, USA, 2012.Vranken, D. V.; Weiss, G. A. Introduction to Bioorganic Chemistry and Chemical Biology; Garland Science: New York, NY, USA, 2012.
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  Miller, A. D.; Tanner, J. Essentials of Chemical Biology Structure and Dynamics of Biological Macromolecules; Wiley: West Sussex, England, 2008.Miller, A. D.; Tanner, J. Essentials of Chemical Biology Structure and Dynamics of Biological Macromolecules; Wiley: West Sussex, England, 2008.
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  Schreiber, S. L.; Kapoor, T. M.; Wess, G. Chemical Biology from Small Molecules to Systems Biology and Drug Design; Wiley-VCH: Weinheim, Germany, 2007.Schreiber, S. L.; Kapoor, T. M.; Wess, G. Chemical Biology from Small Molecules to Systems Biology and Drug Design; Wiley-VCH: Weinheim, Germany, 2007.

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化学“101计划”——化学生物学教材设计与建设

English

Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook

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化学“101计划”——化学生物学教材设计与建设

English

Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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