引用本文:
李姝慧, 黄荣秀媛, 潘英明. 电化学制备2,5-二苯基-1,3,4-噁二唑——推荐一个综合性有机化学实验[J]. 大学化学,
2025, 40(5): 357-365.
doi:
10.12461/PKU.DXHX202407028
Citation: Shuhui Li, Rongxiuyuan Huang, Yingming Pan. Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment[J]. University Chemistry, 2025, 40(5): 357-365. doi: 10.12461/PKU.DXHX202407028
Citation: Shuhui Li, Rongxiuyuan Huang, Yingming Pan. Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment[J]. University Chemistry, 2025, 40(5): 357-365. doi: 10.12461/PKU.DXHX202407028
电化学制备2,5-二苯基-1,3,4-噁二唑——推荐一个综合性有机化学实验
摘要:
本实验采用电化学合成方法，以苯甲酰肼为原料制备2,5-二苯基-1,3,4-噁二唑，并通过核磁、红外、熔点等分析技术对其进行结构鉴定与表征。与传统有机合成方法相比，电化学合成方法符合绿色化学的要求，具有操作简单、条件温和、产率较高等优点。此实验引导学生在掌握了有机基础实验的前提下，对前沿电化学合成方法进行探索研究，并进一步了解电化学在有机合成方面的应用，培养学生的科研兴趣以及创新的科研思维，丰富有机基础实验教学内容。
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关键词:
- 电化学
- / 2,5-二苯基-1,3,4-噁二唑
- / 化学实验教学
- / 有机合成
English
Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment
Abstract:
This experiment employs an electrochemical synthesis method to produce 2,5-diphenyl-1,3,4-oxadiazole from benzoylhydrazine. The structure of the synthesized product is identified and characterized using analytical techniques, including NMR, infrared spectroscopy, and melting point determination. In comparison to traditional organic synthesis methods, the electrochemical approach aligns with green chemistry principles, offering advantages such as simplicity, mild reaction conditions, and high yield. This experiment encourages students, who have mastered fundamental organic laboratory techniques, to explore cutting-edge electrochemical synthesis methods and gain insights into the application of electrochemistry in organic synthesis. Additionally, it fosters students’ interest in scientific research and innovative thinking, thereby enriching the content of basic organic chemistry education.
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[1]
王欢, 陆嘉星. 电化学, 2011, 17 (4), 366.
-
[2]
武现丽, 朱春风, 吕志丹, 魏成事, 廖新成. 有机化学, 2011, 31 (6), 824.
-
[3]
王莉, 刘凯歌, 徐锐, 李亚军. 山西大学学报(自然科学版), 2014, 37 (3), 425.
-
[4]
陈静, 江华. 中国药房, 2015, 26 (13), 1853.
-
[5]
Wang, J.; Wang, L.; Qin, H.; Tian, R.; Pan, Y. Tetrahedron Lett. 2023, 131, 154783.Wang, J.; Wang, L.; Qin, H.; Tian, R.; Pan, Y. Tetrahedron Lett. 2023, 131, 154783.
-
[6]
Ma, H.-Y.; Zha, Z.-G.; Zhang, Z.-L.; Meng, L.; Wang, Z.-Y. Chin. Chem. Lett. 2013, 24 (9), 780.Ma, H.-Y.; Zha, Z.-G.; Zhang, Z.-L.; Meng, L.; Wang, Z.-Y. Chin. Chem. Lett. 2013, 24 (9), 780.
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