车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸

引用本文: 梁一铭, 潘籽言, 陈建成. 车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸[J]. 大学化学, 2025, 40(4): 322-325. doi: 10.12461/PKU.DXHX202406016 shu

Citation: Yiming Liang, Ziyan Pan, Kin Shing Chan. One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions[J]. University Chemistry, 2025, 40(4): 322-325. doi: 10.12461/PKU.DXHX202406016 shu

车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸

1.
南京大学安邦书院, 南京 210023;
2.
南京大学化学化工学院, 南京 210023
基金项目:
南京大学百位名师邀约项目；南京大学国际化课程建设项目；南京大学短期国外专家项目

摘要: 在“人体”工厂中，肝细胞车间主任“小灯”负责代谢乙醇、维护稳定。然而，随着糖尿病、失眠等疾病侵袭，中枢引入了安眠药、降压药等外援。小灯对药物与乙醛脱氢酶可能产生的双硫仑样反应缺乏警惕。一次意外中，头孢药物与乙醇代谢冲突，抑制了乙醛脱氢酶，导致乙醛肆虐，引发混乱。小灯意识到疏忽，加强安保，并向工人传达了领导指示，提醒大家在使用药物时需谨慎。此次危机虽得到控制，但肝细胞们更加明白责任与使命。我们也应从中汲取教训，珍惜生命，避免将生命安全置于危险之中。在表达感情时，有众多选择，完全不必过量饮酒。让我们共同守护这座神奇的工厂，确保它的安全与繁荣。

关键词:

English

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

1.
Anbang Academy, Nanjing University, Nanjing 210023, China;
2.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
Received Date: 11 June 2024
Revised Date: 02 July 2024
Available Online: 02 January 2025

Abstract: In the “human body” factory, the director of the hepatocyte workshop, nicknamed “Xiaodeng”, manages ethanol metabolism to maintain stability. However, with the onset of diseases like diabetes and insomnia, the central nervous system introduces foreign aids such as sedatives and antihypertensive drugs. Xiaodeng inadvertently overlooks the potential disulfiram-like reaction between medications and aldehyde dehydrogenase. In an unfortunate incident, a conflict between cephalosporin drugs and ethanol metabolism inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and ensuing chaos. Recognizing the oversight, Xiaodeng strengthens safety measures and instructs workers to exercise caution when using medications. Although the crisis is contained, this experience underscores the hepatocytes’ enhanced sense of responsibility and mission. We should learn from this and prioritize life, avoiding unnecessary risks such as excessive alcohol consumption. Let us unite in safeguarding this miraculous factory to ensure its safety and prosperity.

Key words:

1. [1]
  Hawkins, R. D.; Kalant, H. Pharmacol. Rev. 1972, 24, 67.Hawkins, R. D.; Kalant, H. Pharmacol. Rev. 1972, 24, 67.
2. [2]
  De Sousa, A. Disulfiram: Pharmacology and Mechanism of Action; Springer: Singapore, 2019; pp. 9–20.De Sousa, A. Disulfiram: Pharmacology and Mechanism of Action; Springer: Singapore, 2019; pp. 9–20.
3. [3]
  Marx, J.; Walls, R.; Hockberger, R. Rosen’s Emergency Medicine: Concepts and Clinical Practice, 8th ed.; Elsevier Health Sciences: Philadelphia, PA, USA, 2013; pp. 2395–2399.Marx, J.; Walls, R.; Hockberger, R. Rosen’s Emergency Medicine: Concepts and Clinical Practice, 8th ed.; Elsevier Health Sciences: Philadelphia, PA, USA, 2013; pp. 2395–2399.
4. [4]
  Williams, S. H. Am. Fam. Physician 2005, 72, 1775.Williams, S. H. Am. Fam. Physician 2005, 72, 1775.
5. [5]
  Vallari, R. C.; Pietruszko, R. Science 1982, 216, 637.Vallari, R. C.; Pietruszko, R. Science 1982, 216, 637.
6. [6]
  Veverka, K. A.; Johnson, K. L.; Mays, D. C.; Lipsky, J. J.; Naylor, S. Biochem. Pharmacol. 1997, 53, 511.Veverka, K. A.; Johnson, K. L.; Mays, D. C.; Lipsky, J. J.; Naylor, S. Biochem. Pharmacol. 1997, 53, 511.
7. [7]
  Stork, C. M. Goldfrank’s Toxicologic Emergencies; McGraw-Hill: New York, NY, USA, 2006; pp. 847–848.Stork, C. M. Goldfrank’s Toxicologic Emergencies; McGraw-Hill: New York, NY, USA, 2006; pp. 847–848.
8. [8]
  Mergenhagen, K. A.; Wattengel, B. A.; Skelly, M. K.; Clark, C. M.; Russo, T. A. Antimicrob. Agents Chemother. 2020, 64, e02167.Mergenhagen, K. A.; Wattengel, B. A.; Skelly, M. K.; Clark, C. M.; Russo, T. A. Antimicrob. Agents Chemother. 2020, 64, e02167.
9. [9]
  Ghosh, A.; Mahintamani, T.; Balhara, Y. P. S.; Roub, F. E.; Basu, D.; Bn, S.; Mattoo, S. K.; Mishra, E.; Sharma, B. Alcohol. Alcohol. (Oxford, U. K.) 2021, 56, 42.Ghosh, A.; Mahintamani, T.; Balhara, Y. P. S.; Roub, F. E.; Basu, D.; Bn, S.; Mattoo, S. K.; Mishra, E.; Sharma, B. Alcohol. Alcohol. (Oxford, U. K.) 2021, 56, 42.

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸

English

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸

English

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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