Abstract: The National Experimental Teaching Demonstration Center for Chemistry at the Dalian University of Technology adheres to the educational purpose of “emphasizing foundation, cultivating abilities, and shaping personality”, and the educational philosophy of student-centered development. It fully plays the main battlefield role of talent cultivation and has conducted in-depth exploration and research in the construction of experimental teaching system, teaching resource construction, laboratory management, and teacher team construction. After 5 years of construction practice, a “four in one” experimental teaching system and an “integrated” new paradigm of safety education have been constructed, and a “series, digital, and multimodal” experimental teaching resource has been created. A first-class laboratory environment and institutional guarantee have been established, and a “teacher led” experimental teaching team has been formed. This has promoted the improvement of students' abilities in independent exploration, innovative practice, and emergency response.