海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践

引用本文: 杨文军, 谭巧玲, 谢文姣, 潘晓玉, 袁友永. 海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践[J]. 大学化学, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150 shu

Citation: Wenjun Yang, Qiaoling Tan, Wenjiao Xie, Xiaoyu Pan, Youyong Yuan. Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments[J]. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150 shu

海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践

华南理工大学生物医学科学与工程学院, 广州国际校区, 广州 511442

通讯作者: 袁友永,E-mail:yuanyy@scut.edu.cn

基金项目:
华南理工大学校级教研教改项目(2024年)；华南理工大学校级研究生课程建设项目；广东省研究生教育创新计划项目(2023XSLT_005)

摘要: 在追求培养高素质应用型人才的教育目标指引下，本文提出了一个综合性实验模块，该模块融合了高分子化学、生物医学工程和仪器分析等学科领域的基础知识与实验技能。本实验以磷酸钙作为凝胶化的钙源，通过精确调控氯化钙与磷酸钠溶液混合比例及过程，实现了磷酸钙颗粒在天然高分子海藻酸钠溶液中的均匀分散。这些颗粒在搅拌作用下缓慢释放钙离子，与海藻酸钠发生交联反应，从而形成粒径在微米范围内的海藻酸钙凝胶颗粒，并在此过程中实现对药物的高效包载。实验中运用了动态光散射技术来评估颗粒的粒径及分布，通过荧光分光光度法来分析其药物包载效率及释放行为。本实验方案立足于当前科研领域的热点，并采用了经过广泛验证的环保材料与方法，保证了实验的生态友好性。同时，该实验模型具有潜在的拓展性，可适用于其他响应型高分子及药物载体的研究。本实验设计旨在同步促进学生的基础实验技能与高级研究素养，通过在探索性学习环境中对学生进行指导，进一步激发和提升他们的创新思维和自主研究能力，从而培育出能够引领未来科研领域发展的创新型人才。

关键词:

English

Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments

School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China

Corresponding author: Youyong Yuan, yuanyy@scut.edu.cn

Received Date: 22 May 2024
Revised Date: 04 July 2024
Available Online: 21 February 2025

Abstract: Guided by the educational objective of cultivating high-quality applied talents, this paper proposes a comprehensive experimental module that integrates fundamental knowledge and experimental skills from polymer chemistry, biomedical engineering, and instrumental analysis. In this experiment, calcium phosphate is employed as the calcium source for gelation. By precisely controlling the mixing ratio and process of calcium chloride and sodium phosphate solutions, calcium phosphate particles are uniformly dispersed in sodium alginate, a natural polymer. Under stirring, these particles gradually release calcium ions, which react with sodium alginate to form calcium alginate gel particles with micrometer-scale sizes, while achieving efficient drug encapsulation. Dynamic light scattering technique is employed to evaluate particle size and distribution, and fluorescence spectrophotometry is applied to analyze drug encapsulation efficiency and release behavior. This experimental design is based on current research hotspots and utilizes environmentally friendly materials and methods, ensuring its ecological friendliness. Moreover, the experimental model has potential expandability and can be applied to studies of other responsive polymers and drug carriers. The experiment is designed to simultaneously enhance students’ basic experimental skills and advanced research competence, fostering innovative thinking and independent research abilities. Through guidance in an exploratory learning environment, the module aims to nurture innovative talents capable of driving future scientific development

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践

通讯作者: 袁友永,E-mail:yuanyy@scut.edu.cn

English

Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments

Corresponding author: Youyong Yuan, yuanyy@scut.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

海藻酸钙微米凝胶载药颗粒的构建及表征——高分子实验的新设计与教学实践

通讯作者: 袁友永,E-mail:yuanyy@scut.edu.cn

English

Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments

Corresponding author: Youyong Yuan, yuanyy@scut.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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